We make your cryo-EM sample preparation more reliable
- Get better grids from your most challenging samples
- Get more grids out of your little amount of precious protein
- Minimize the air-water interface effects during the vitrification process
- Integrate nanoscale protein isolation and grid preparation into one fast and gentle step
CryoWrite develops automated sample preparation robots for cryo-EM. Our first product is the cryoWriter. This is a pipette-based robot that can dispensing nanoliter volumes of samples on a cryo-EM grid. As a result, this makes the technology blottless, thus omitting the potentially harmfull blotting step. There are many other features that address some of the crucial challenges during cryo-EM sample preparation. In addition, our pipette based solution enables new, unique features that rely on the capillary for sample manipulation.
Read more about our sample preparation solution and its capabilities:
Our product: The cryoWriter
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How to…: General info about cryo-EM and cryo-ET
Do you want to learn more about the principles of cryo-EM and cryo-ET? Researchers at the University of Utah give a great overview from sample purification, grid prepration, screen and evaluation to data collection and image processing. Their website, cryoem101.org, contains chapters for the different steps in the workflow. The text is illustrated with videos and animations and interactive simulations, well explaining what is going on.
Chapter 2 contains many aspects and challenges to consider during grid preparation.
