Innosuisse has approved CHF 1.55 million in non-dilutive funding to support cryoWrite’s development into a scalable, commercial product. We are very grateful for this support and look forward to executing the project efficiently. In the meantime, we will continue to supply a limited number of cryoWriters to select labs from our small-scale production facility. It is truly impressive to see the innovative methods researchers have already developed using the few units delivered so far.
Our collaborators at the Biozentrum integrated single-cell lysis with mass spectrometry and reverse-phase protein arrays, enabling correlative single- and few-cell analyses that combine light microscopy with metabolomics and targeted proteomics.
Originally, CryoWriter technology was developed for single-cell analysis via electron microscopy (single-cell visual proteomics), with its writing system directly coupled to a single-cell lysis method for adherent eukaryotic cells. Now, the system integrates light microscopy, cell targeting, and lysis with liquid chromatography-mass spectrometry for single-cell metabolite detection and protein microarrays for protein analysis.
These technologies paves the way for correlative multiomics analysis on the single cell level!
Relevant publications for single-cell visual proteomics:
- Syntychaki A, Rima L, Schmidli C, Stohler T, Bieri A, Sütterlin R, et al. `Differential visual proteomics’: Enabling the proteome-wide comparison of protein structures of single-cells. J Proteome Res. 2019;18(9):3521–31.
- Arnold SA, Albiez S, Opara N, Chami M, Schmidli C, Bieri A, et al. Total sample conditioning and preparation of nanoliter volumes for electron microscopy. ACS Nano. 2016;10(5):4981–8.
- Kemmerling S, Arnold SA, Bircher BA, Sauter N, Escobedo C, Dernick G, et al. Single-cell lysis for visual analysis by electron microscopy. J Struct Biol. 2013;183:467–73.
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Our Team is Growing!
Currently, there are no open positions available (as of 2025-07-19).
We’ve recently welcomed and will welcome many talented new employees, expanding our collective expertise. Stay tuned for more details about the exceptional people who make CryoWrite so fantastic.
Please check our About us page, which is continuously updated.
Please note that all positions have been filled in the meantime (as of 2025-07-10)
We are thrilled to announce that cryoWrite AG is expanding!
As our company grows, we eagerly seek talented individuals to join our dynamic team. We have several open positions and are looking for enthusiastic professionals passionate about driving innovation in the field of electron microscopy.
Current openings
- Application Scientists (2 positions): We are looking for candidates with experience in electron microscopy and high-resolution data analysis to join our team. Your expertise will be pivotal in advancing our cutting-edge technologies. More information: Application Scientist.
- Robotics Software Engineer: Do you have a strong background in software development (ROS, Python, QT) and robotics control? We have an exciting opportunity for you to expand our software and work closely with our development and application teams. More information: Software Engineer / Robotics.
- Mechanical Engineer: If you have a strong background in mechanical engineering and CAD experience, we want you to strengthen our development team and contribute to the design and enhancement of our products.
- Application Engineer: This role involves further developing the cryoWriter instrument, overseeing the assembly process, and providing exceptional customer support. Experience in mechatronics and a passion for innovative technology are critical.
About cryoWrite AG
Founded in 2020 as a spin-off from the University of Basel, cryoWrite AG specializes in fully automated robotics for microfluidic sample preparation in electron microscopy. Our pioneering approaches include novel strategies for protein isolation and single-cell analysis, making significant contributions to scientific research. Our offices are located in Basel, a vibrant city known for its rich cultural and scientific heritage, offering an inspiring environment in which to live and work.
Interested?
We would love to hear from you!
For more information or to apply, please email thomas.braun@cryowrite.com.
Join us at cryoWrite AG and be a part of a team shaping the future of electron microscopy!
Armin Ruf is at the ECM34 in Padova, the European Crystallographic Meeting. Moreover, on Thursday he will be presenting a poster about the latest developments of the cryoWriter. More precisely, he will be at poster 15 on the ground floor in the MS09 poster session. In addition, he is looking forward to discuss proteins, their structures, and their preparation for cryoEM.
If you are at the conference, go and have a chat with him at the poster or during one of the breaks.
Andreas Engel is at the EMC 2024 in Copenhagen. So, if you want to learn about the latest developments of the cryoWriter, go and visit him. In addition, he will be happy to discuss your application or sample preparation for cryoEM in general. You can find him at the booth of TVIPS (A33) right at the entrance of the exhibition hall.
Today we published a new application note on cold-writing. Our cold-writing protocol improves reproducible grid preparation. With this protocol we routinely get over 100 squares with vitrified ice per grid. And even fragile samples like liposomes can be applied on the grid.
Do you want to learn more? Visit the application section of the cryoWriter
GRC on 3D EM with special session on specimen preparation challenges and solutions
The Gordon Research Conference on 3D EM (Three dimensional Electron Microscopy) 2024 takes place in Spain in June. This year, the GRC focuses on “bridging gaps between cell, structural and computational biology”. To this end, it has a special session on “specimen preparation challenges and solutions”. With this session, the conference addresses the existing bottleneck in sample preparation for cryo-EM. It is therefore our pleasure to announce that Andreas Engel will present how a solution using an automated pipette-robot can make sample preparation more reliable. The use of pipettes even enables integration of extra inline preparation steps.
If you are interested to join, please check the GRC website for application information on attendance of this meeting.
After looking back on a successful business year 2023, we are now looking ahead again. We start the new year with expanding the team and hiring a new colleague.
With Nadia Antoniadis, we recruited a new application scientist at cryoWrite to support our customers and the implementation of new modules on the cryoWriter. Nadia has a bachelor’s degree in Nanoscience and did her Masters and PhD in experimental physics. After having worked on quantum computing, she will be applying her skills on more biological applications.
We are glad having Nadia in the team and look forward on her contribution to many, exciting applications of the cryoWriter.
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Season’s greetings 2023
It is Christmas time: Instead of dispensing proteins on hydrophilized grids in a spiral form, we provided the cryoWriter with coordinates in a different pattern! We omitted the on-board glow discharger to keep a better confinement of the tree and used ink to better see it in the camera.
We wish you all Merry Christmas and a good start in 2024.
