M&M in Minneapolis, MN – July 23-27, 2023: Tietz Video & Image Processing Systems GmbH provides information about the cryoWriter system at booth 1019.
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cryoWrite moved to new premises
cryoWrite moved: cryoWrite AG is growing and urgently needs more space. Therefore, we moved and finally have enough space for developing, building, and delivering cryoWriters!
See also the new How to reach us page.
We are incredibly proud to have reached a significant milestone for our startup company: The first cryoWriter was delivered! Our customer is the group of Prof. Stahlberg at the EPFL in Lausanne, Switzerland.
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Back from MC2023 Darmstadt
We had our first product exposition at the MC2023 Darmstadt! From the 26.02.-02.03.2023 cryoWrite was a guest of Tietz Video & Image Processing Systems GmbH to present the cryoWriter system.
The order for the second cryoWriter is from a local pharmaceutical industry: we are over the moon!
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MC2023 Darmstadt
MC2023 Darmstadt, 26.02.-02.03.2023: cryoWrite AG presents the cryoWriter for the first time as a guest of Tietz Video & Image Processing Systems GmbH.
Together with cryoWrite and Roche, a research group in the Biozentrum of the University Basel presented a Faraday Discussion paper improving the grid quality and reducing background noise using cryoWriter technology. They use a “coverslip” injector to modulate the air-water interface with amphiphilic molecules:
- Rima, L.; Zimmermann, M.; Fränkl, A.; Clairfeuille, T.; Lauer, M.; Engel, A.; Engel, H.-A.; Braun, T. CryoWriter: A Blotting Free Cryo-EM Preparation System with a Climate Jet and Cover-Slip Injector. Faraday Discussions2022. https://doi.org/10.1039/D2FD00066K.
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cryoWriter Technology in action
Here you will find an early video explaining the cryoWriter technology for negative stain, cryo-EM, and single-cell visual proteomics.
References
Reference for the video:
- Schmidli, C.; Rima, L.; Arnold, S. A.; Stohler, T.; Syntychaki, A.; Bieri, A.; Albiez, S.; Goldie, K. N.; Chami, M.; Stahlberg, H.; Braun, T. Miniaturized Sample Preparation for Transmission Electron Microscopy. JoVE2018, No. 137, e57310. https://doi.org/10.3791/57310.
The video summarizes technologies and methods published before:
- Kemmerling, S.; Ziegler, J.; Schweighauser, G.; Arnold, S. A.; Giss, D.; Müller, S. A.; Ringler, P.; Goldie, K. N.; Goedecke, N.; Hierlemann, A.; Stahlberg, H.; Engel, A.; Braun, T. Connecting 𝜇-Fluidics to Electron Microscopy. J. Struct. Biol.2012, 177 (1), 128–134. https://doi.org/10.1016/j.jsb.2011.11.001.
- Arnold, S. A.; Albiez, S.; Opara, N.; Chami, M.; Schmidli, C.; Bieri, A.; Padeste, C.; Stahlberg, H.; Braun, T. Total Sample Conditioning and Preparation of Nanoliter Volumes for Electron Microscopy. ACS Nano2016, 10 (5), 4981–4988. https://doi.org/10.1021/acsnano.6b01328.
- Kemmerling, S.; Arnold, S. A.; Bircher, B. A.; Sauter, N.; Escobedo, C.; Dernick, G.; Hierlemann, A.; Stahlberg, H.; Braun, T. Single-Cell Lysis for Visual Analysis by Electron Microscopy. J. Struct. Biol.2013, 183, 467–473. https://doi.org/10.1016/j.jsb.2013.06.012.
- Arnold, S. A.; Albiez, S.; Bieri, A.; Syntychaki, A.; Adaixo, R.; McLeod, R. A.; Goldie, K. N.; Stahlberg, H.; Braun, T. Blotting-Free and Lossless Cryo-Electron Microscopy Grid Preparation from Nanoliter-Sized Protein Samples and Single-Cell Extracts. J. Struct. Biol.2017, 197 (3), 220–226. https://doi.org/10.1016/j.jsb.2016.11.002.
